Here is a guide to quickly make your RMsis Installation operational.

Ensure that your system meets the hardware and software requirements, as mentioned in System Requirements.

if you do not have JIRA installed on your server, here is a guide to get started : https://confluence.atlassian.com/display/JIRA/JIRA+101
Create Project(s) in JIRA
Configure User(s) in JIRA

RMsis synchronizes with JIRA and this synchronization is done, every time a user clicks on the RMsis link on JIRA Menu Bar.
So a project configured in JIRA will automatically become visible in RMsis (unless explicitly disabled by the administrator in the versions 1.7.0 or greater).
All projects can be configured using the options as described here RMsis Application Configuration
Project specific configuration options are available from RMsis 1.7.0 onwards.

All users belonging to jira-users group will automatically become available in RMsis, subject to the availability of licenses.
Other roles in JIRA are optional, from access perspective.
The Project Lead / Manager in JIRA will become the Project Manager in RMsis by default.
Administrators in JIRA will automatically have administrative roles in RMsis.
Administrator can enable or disable users, as described here : RMsis administration by Tool Admin
Administrator can Create / Edit roles, as described here Permissions, and their assignment to Roles and Roles and Access Rights
Project Manager can assign roles to users, as described here : User administration by Requirement Manager

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